Revision as of 23:39, 28 June 2026

Single-molecule detection

Single-molecule detection refers to methods that observe individual molecules rather than measuring only bulk averages. Nanopores are useful for single-molecule sensing because each molecule can produce a distinct signal while interacting with the pore.

What can be detected

DNA and RNA molecules.
Peptides and proteins.
Small molecules and metabolites.
Biomarkers related to disease or environmental monitoring.

Why it matters

Single-molecule methods can reveal heterogeneity, rare events, molecular modifications, and transient interactions that may be hidden in ensemble measurements.

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-<div class="plainlinks">'''Languages:''' [[Single-molecule detection|English]] | [[Single-molecule detection/zh|中文]] | [[Single-molecule detection/es|español]] | [[Single-molecule detection/fr|français]] | [[Single-molecule detection/de|Deutsch]] | [[Single-molecule detection/ja|日本語]]</div>
+<div lang="en" dir="ltr" class="mw-content-ltr">
+= Single-molecule detection =
+</div>
-= 単分子検出 =
+<div lang="en" dir="ltr" class="mw-content-ltr">
+'''Single-molecule detection''' refers to methods that observe individual molecules rather than measuring only bulk averages. Nanopores are useful for single-molecule sensing because each molecule can produce a distinct signal while interacting with the pore.
+</div>
-'''単分子検出'''は、個々の分子を観察する方法を指し、全体の平均値だけを測定するのではなく、個々の分子を観察します。ナノポアは、単分子センシングに有用です。なぜなら、各分子がポアと相互作用する際に独自の信号を生成するからです。
+<div lang="en" dir="ltr" class="mw-content-ltr">
+== What can be detected ==
+</div>
-== 検出可能な物質 ==
+<div lang="en" dir="ltr" class="mw-content-ltr">
+* DNA and RNA molecules.
+* Peptides and proteins.
+* Small molecules and metabolites.
+* Biomarkers related to disease or environmental monitoring.
+</div>
-* DNA および RNA 分子。
+<div lang="en" dir="ltr" class="mw-content-ltr">
-* ペプチドおよびタンパク質。
+== Why it matters ==
-* 小分子および代謝物。
+</div>
-* 疾病や環境モニタリングに関連するバイオマーカー。
-== なぜ重要なのか ==
+<div lang="en" dir="ltr" class="mw-content-ltr">
+Single-molecule methods can reveal heterogeneity, rare events, molecular modifications, and transient interactions that may be hidden in ensemble measurements.
+</div>
-単分子法は、集団測定では隠れてしまう可能性のある異質性、稀な事象、分子の修飾、一時的な相互作用を明らかにすることができます。
+<div lang="en" dir="ltr" class="mw-content-ltr">
+== Related pages ==
+</div>
-== 関連ページ ==
+<div lang="en" dir="ltr" class="mw-content-ltr">
+* [[Nanopore technology]]
+* [[Nanopore sequencing]]
+* [[Bioinformatics]]
+</div>
-* [[ナノポア技術]]
+<languages />
-* [[ナノポアシーケンス]]
-* [[バイオインフォマティクス]]