Revision as of 23:39, 28 June 2026

Single-molecule detection

Single-molecule detection refers to methods that observe individual molecules rather than measuring only bulk averages. Nanopores are useful for single-molecule sensing because each molecule can produce a distinct signal while interacting with the pore.

What can be detected

DNA and RNA molecules.
Peptides and proteins.
Small molecules and metabolites.
Biomarkers related to disease or environmental monitoring.

Why it matters

Single-molecule methods can reveal heterogeneity, rare events, molecular modifications, and transient interactions that may be hidden in ensemble measurements.

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-<div class="plainlinks">'''Languages:''' [[Single-molecule detection|English]] | [[Single-molecule detection/zh|中文]] | [[Single-molecule detection/es|español]] | [[Single-molecule detection/fr|français]] | [[Single-molecule detection/de|Deutsch]] | [[Single-molecule detection/ja|日本語]]</div>
+<div lang="en" dir="ltr" class="mw-content-ltr">
+= Single-molecule detection =
+</div>
-= 单分子检测 =
+<div lang="en" dir="ltr" class="mw-content-ltr">
+'''Single-molecule detection''' refers to methods that observe individual molecules rather than measuring only bulk averages. Nanopores are useful for single-molecule sensing because each molecule can produce a distinct signal while interacting with the pore.
+</div>
-'''单分子检测'''是指观察单个分子而不是仅测量整体平均值的方法。纳米孔对于单分子传感非常有用，因为每个分子在与孔相互作用时可以产生独特的信号。
+<div lang="en" dir="ltr" class="mw-content-ltr">
+== What can be detected ==
+</div>
-== 可以检测什么 ==
+<div lang="en" dir="ltr" class="mw-content-ltr">
+* DNA and RNA molecules.
+* Peptides and proteins.
+* Small molecules and metabolites.
+* Biomarkers related to disease or environmental monitoring.
+</div>
-* DNA和RNA分子。
+<div lang="en" dir="ltr" class="mw-content-ltr">
-* 肽和蛋白质。
+== Why it matters ==
-* 小分子和代谢物。
+</div>
-* 与疾病或环境监测相关的生物标志物。
-== 为什么重要 ==
+<div lang="en" dir="ltr" class="mw-content-ltr">
+Single-molecule methods can reveal heterogeneity, rare events, molecular modifications, and transient interactions that may be hidden in ensemble measurements.
+</div>
-单分子方法可以揭示在整体测量中可能被隐藏的异质性、稀有事件、分子修饰和瞬时相互作用。
+<div lang="en" dir="ltr" class="mw-content-ltr">
+== Related pages ==
+</div>
-== 相关页面 ==
+<div lang="en" dir="ltr" class="mw-content-ltr">
+* [[Nanopore technology]]
+* [[Nanopore sequencing]]
+* [[Bioinformatics]]
+</div>
-* [[Nanopore technology|纳米孔技术]]
+<languages />
-* [[Nanopore sequencing|纳米孔测序]]
-* [[Bioinformatics|生物信息学]]