Main Page: Difference between revisions

Latest revision as of 11:47, 30 June 2026

Featured Topic

Principle of nanopore sequencing.

Nanopores are nanoscale openings that allow ions or molecules to pass through a membrane or solid-state material. When a molecule moves through or near a nanopore, it can change an electrical current, ion flow, or another measurable signal. These signal changes can be used to study DNA, RNA, proteins, small molecules, and other biological or chemical systems at single-molecule scale.

Did You Know?

Nanopore sequencing reads molecular signals directly as DNA or RNA passes through a nanoscale pore.
Long reads can help resolve repeats, structural variants, and complex genome regions.
Some nanopore methods can detect RNA or base modifications without converting molecules into short amplified fragments.
Portable instruments make sequencing possible in field, classroom, clinical, and small-laboratory settings.

Picture of the Day

A schematic view of nanopore sequencing, where molecular movement through a pore is converted into measurable signal.

News and Research Updates

2026-06-27 - Nanopore Wiki homepage launched with a portal-style layout for tracking nanopore technology, sequencing, tools, and research progress.

Start Here

Nanopore technology - principles, pore types, signals, and measurement concepts.
Nanopore sequencing - how DNA and RNA sequencing with nanopores works.
Single-molecule detection - how nanopores can detect individual molecules.
Bioinformatics - basecalling, read mapping, assembly, variants, and quality control.
Glossary - concise definitions of common terms.

Nanopore Wiki Reminds You

Nanopore Wiki is an educational and knowledge-organization project. Its pages are intended for science communication and general technical reference, and do not replace professional medical, legal, regulatory, or commercial advice. Claims about breakthroughs, clinical use, or product performance should be supported by reliable sources.

Knowledge Areas

Methods

Community

Nanopore Wiki is a knowledge and science-outreach project. The site can reserve space for related multilingual, open-content tasks and community-maintained resources:

G	Glossary Concise definitions for nanopore terms.	N	News and papers Research updates, high-level papers, and technology progress.
D	Data and bioinformatics Workflows for signal, reads, mapping, assembly, and variants.	I	Instruments and workflows Portable sequencing devices and practical methods.
H	Help How to read, search, and contribute.	E	Editorial guidelines Quality standards for rigorous writing and sourcing.

@@ Line 1: / Line 1: @@
-= Welcome to Nanopore Wiki =
+__NOTOC__
+<translate>
+<!--T:1-->
+<div id="np-2012">
+<div id="np-2012-banner">
+<div id="np-2012-banner-title">
+<h1>Nanopore Wiki</h1>
+<p>A rigorous, multilingual knowledge base for nanopore technology, sequencing, single-molecule sensing, and bioinformatics.</p>
+</div>
+<div id="np-2012-banner-intro">
+<p>Start from concepts, follow reliable sources, and track frontier research.</p>
+<table><tr><td>[[Nanopore technology|Technology]]</td><td>[[Nanopore sequencing|Sequencing]]</td><td>[[Bioinformatics|Bioinformatics]]</td></tr><tr><td>[[Glossary|Glossary]]</td><td>[[Latest Progress|Progress]]</td><td>[[Help:Contents|Help]]</td></tr></table>
+</div>
+</div>
-[[File:Nanopore_sequencing_principle.png|thumb|right|360px|Principle of nanopore sequencing. Source: Wikimedia Commons, DBCLS, CC BY 4.0.]]
+<!--T:2-->
+<div id="np-2012-body">
+<div id="np-2012-column-left">
+<div class="np-2012-block"><h2>Featured Topic</h2><div class="np-2012-text">
+<div class="np-2012-image">[[File:Nanopore_sequencing_principle.png|frameless|220px|link=https://www.nanopore.net/index.php?curid=2|Principle of nanopore sequencing]]<div class="np-2012-caption">Principle of nanopore sequencing.</div></div>
+Nanopores are nanoscale openings that allow ions or molecules to pass through a membrane or solid-state material. When a molecule moves through or near a nanopore, it can change an electrical current, ion flow, or another measurable signal. These signal changes can be used to study DNA, RNA, proteins, small molecules, and other biological or chemical systems at single-molecule scale.
+</div></div>
-'''Nanopore Wiki''' is a knowledge base and science outreach site focused on nanopore technology and frontier science. The site covers nanopore sequencing, single-molecule detection, bioinformatics, experimental workflows, instrument platforms, research progress, and related foundational concepts. Its goal is to organize scattered technical materials into a clear, searchable, and continuously updated knowledge system.
+<!--T:3-->
+<div class="np-2012-block"><h2>Did You Know?</h2><div class="np-2012-text">
+* Nanopore sequencing reads molecular signals directly as DNA or RNA passes through a nanoscale pore.
+* Long reads can help resolve repeats, structural variants, and complex genome regions.
+* Some nanopore methods can detect RNA or base modifications without converting molecules into short amplified fragments.
+* Portable instruments make sequencing possible in field, classroom, clinical, and small-laboratory settings.
+</div></div>
-== What Is a Nanopore? ==
+<!--T:4-->
+<div class="np-2012-block"><h2>Picture of the Day</h2><div class="np-2012-text">
+[[File:Nanopore_sequencing_principle.png|frameless|300px|center|link=https://www.nanopore.net/index.php?curid=2|Principle of nanopore sequencing]]
+<div class="np-2012-caption">A schematic view of nanopore sequencing, where molecular movement through a pore is converted into measurable signal.</div>
+</div></div>
+</div>
-A '''nanopore''' usually refers to a nanoscale pore. It may exist in biological membrane proteins or be fabricated from solid-state materials. The core idea is that when ions, DNA, RNA, proteins, or other molecules pass through an extremely small pore, they change the electrical current, ion flow, or other measurable signals in the pore. Researchers can use these signal changes to infer a molecule's size, structure, composition, or movement.
+<!--T:5-->
+<div id="np-2012-column-right">
+<div class="np-2012-block"><h2>News and Research Updates</h2><div class="np-2012-text">
+{{:Latest Progress}}
+</div></div>
-Nanopores are not only used for DNA or RNA sequencing. They can also be used to detect small molecules, peptides, proteins, biopolymers, carbohydrates, and disease biomarkers, with potential applications in environmental monitoring, food safety, metabolite analysis, and other fields.
+<!--T:6-->
+<div class="np-2012-block"><h2>Start Here</h2><div class="np-2012-text">
+* [[Nanopore technology]] - principles, pore types, signals, and measurement concepts.
+* [[Nanopore sequencing]] - how DNA and RNA sequencing with nanopores works.
+* [[Single-molecule detection]] - how nanopores can detect individual molecules.
+* [[Bioinformatics]] - basecalling, read mapping, assembly, variants, and quality control.
+* [[Glossary]] - concise definitions of common terms.
+</div></div>
-== What Is Nanopore Sequencing? ==
+<!--T:7-->
+<div class="np-2012-block"><h2>Nanopore Wiki Reminds You</h2><div class="np-2012-text">
+Nanopore Wiki is an educational and knowledge-organization project. Its pages are intended for science communication and general technical reference, and do not replace professional medical, legal, regulatory, or commercial advice. Claims about breakthroughs, clinical use, or product performance should be supported by reliable sources.
+</div></div>
+</div>
+</div>
-'''Nanopore sequencing''' is a type of third-generation sequencing technology. It typically allows a single DNA or RNA molecule to pass through a nanopore and measures the changes in electrical signals as the molecule moves through the pore, making it possible to infer the nucleic acid sequence.
+<!--T:8-->
+<div id="np-2012-links">
+<table><tr>
+<td><h3>Knowledge Areas</h3>
+* [[Nanopore technology|Technology]]
+* [[Nanopore sequencing|Sequencing]]
+* [[Single-molecule detection|Single-molecule detection]]
+</td>
+<td><h3>Methods</h3>
+* [[Bioinformatics|Bioinformatics]]
+* [[MinION|Instruments]]
+* [[Oxford Nanopore|Platforms]]
+</td>
+<td><h3>Community</h3>
+* [[Latest Progress|News and papers]]
+* [[Help:Contents|Help]]
+* [[Nanopore Wiki:Editorial guidelines|Editorial guidelines]]
+</td>
+</tr></table>
+</div>
-Compared with many traditional sequencing methods, nanopore sequencing has several distinctive features:
+<!--T:9-->
+<div id="np-2012-sisters">
-* It can directly read single DNA or RNA molecules.
+<p><b>Nanopore Wiki</b> is a knowledge and science-outreach project. The site can reserve space for related multilingual, open-content tasks and community-maintained resources:</p>
-* In many scenarios, it does not require PCR amplification or fluorescent labeling.
+<table>
-* Devices can be miniaturized and made portable, making them suitable for field detection.
+<tr><td class="np-sister-mark">G</td><td><b>[[Glossary|Glossary]]</b><br />Concise definitions for nanopore terms.</td><td class="np-sister-mark">N</td><td><b>[[Latest Progress|News and papers]]</b><br />Research updates, high-level papers, and technology progress.</td></tr>
-* Data can be generated and analyzed in real time.
+<tr><td class="np-sister-mark">D</td><td><b>[[Bioinformatics|Data and bioinformatics]]</b><br />Workflows for signal, reads, mapping, assembly, and variants.</td><td class="np-sister-mark">I</td><td><b>[[MinION|Instruments and workflows]]</b><br />Portable sequencing devices and practical methods.</td></tr>
-* Long-read capability is useful for genome assembly, structural variant analysis, and haplotype studies.
+<tr><td class="np-sister-mark">H</td><td><b>[[Help:Contents|Help]]</b><br />How to read, search, and contribute.</td><td class="np-sister-mark">E</td><td><b>[[Nanopore Wiki:Editorial guidelines|Editorial guidelines]]</b><br />Quality standards for rigorous writing and sourcing.</td></tr>
+</table>
-== Typical Applications ==
+</div>
-* '''Pathogen detection''': Rapid identification of viruses, bacteria, and other pathogens.
-* '''Public health surveillance''': For example, variant tracking and wastewater monitoring during outbreaks.
-* '''Environmental monitoring''': Research on environmental DNA, microbial communities, and pollution-related questions.
-* '''Agriculture and food safety''': Crop disease detection, food contamination analysis, and traceability.
-* '''Genome research''': Sequencing of human, animal, plant, and microbial genomes.
-* '''Epigenetics and modification detection''': Exploration of methylation and other base modification signals.
-* '''Single-molecule sensing''': Extension to proteins, small molecules, and biomarkers.
-== Site Positioning ==
-* '''Knowledge base''': A place to collect searchable and updatable topic pages and learning materials.
-* '''Science outreach site''': Clear and accurate explanations of nanopore technology and its applications.
-* '''Frontier watch''': Tracking important papers, tools, methods, and industry developments.
-* '''Practical reference''': Notes on experimental workflows, data analysis approaches, and common questions.
-== Recommended Entry Points ==
-* [[Nanopore technology]]
-* [[Nanopore sequencing]]
-* [[Single-molecule detection]]
-* [[Bioinformatics]]
-* [[Oxford Nanopore]]
-* [[MinION]]
-* [[Research progress]]
-* [[Glossary]]
-== Editorial Principles ==
-* Base content on reliable sources and avoid unverified claims.
-* Distinguish facts, explanations, hypotheses, and opinions.
-* Encourage continuous revision so pages improve as knowledge evolves.
-* Serve readers in clear English while preserving technical accuracy for specialist users.
+<!--T:10-->
 == References ==
 * [https://en.wikipedia.org/wiki/Nanopore Nanopore - Wikipedia]
 * [https://en.wikipedia.org/wiki/Nanopore_sequencing Nanopore sequencing - Wikipedia]
 * [https://commons.wikimedia.org/wiki/File:202001_nanopore_sequencing.svg Principle of nanopore sequencing - Wikimedia Commons]
+</div>
+</translate>
+<languages />