Single-molecule detection: Difference between revisions
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'''Single-molecule detection''' refers to methods that observe individual molecules rather than measuring only bulk averages. Nanopores are useful for single-molecule sensing because each molecule can produce a distinct signal while interacting with the pore. | '''Single-molecule detection''' refers to methods that observe individual molecules rather than measuring only bulk averages. Nanopores are useful for single-molecule sensing because each molecule can produce a distinct signal while interacting with the pore. | ||
== What can be detected == | == What can be detected == <!--T:3--> | ||
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* DNA and RNA molecules. | * DNA and RNA molecules. | ||
* Peptides and proteins. | * Peptides and proteins. | ||
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* Biomarkers related to disease or environmental monitoring. | * Biomarkers related to disease or environmental monitoring. | ||
== Why it matters == | == Why it matters == <!--T:5--> | ||
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Single-molecule methods can reveal heterogeneity, rare events, molecular modifications, and transient interactions that may be hidden in ensemble measurements. | Single-molecule methods can reveal heterogeneity, rare events, molecular modifications, and transient interactions that may be hidden in ensemble measurements. | ||
== Related pages == | == Related pages == <!--T:7--> | ||
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* [[Nanopore technology]] | * [[Nanopore technology]] | ||
* [[Nanopore sequencing]] | * [[Nanopore sequencing]] | ||
* [[Bioinformatics]] | * [[Bioinformatics]] | ||
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Latest revision as of 22:38, 28 June 2026
Single-molecule detection
Single-molecule detection refers to methods that observe individual molecules rather than measuring only bulk averages. Nanopores are useful for single-molecule sensing because each molecule can produce a distinct signal while interacting with the pore.
What can be detected
- DNA and RNA molecules.
- Peptides and proteins.
- Small molecules and metabolites.
- Biomarkers related to disease or environmental monitoring.
Why it matters
Single-molecule methods can reveal heterogeneity, rare events, molecular modifications, and transient interactions that may be hidden in ensemble measurements.