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← Older revision		Revision as of 13:43, 29 June 2026
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	__NOTOC__		__NOTOC__
	<div class="np-portal">		<div class="np-portal">
	<div class="np-~~hero~~">		<div class="np-welcome">
	~~<div~~>		<div class="np-welcome-title">Welcome to Nanopore Wiki</div>
	<div class="np-~~hero~~-title">Welcome to Nanopore Wiki</div>		<div class="np-welcome-subtitle">A knowledge base and science outreach site for nanopore technology, sequencing, single-molecule detection, bioinformatics, instruments, and frontier research.</div>
	<div class="np-~~hero~~-subtitle">A knowledge base and science outreach site for nanopore technology, ~~nanopore~~ sequencing, single-molecule ~~sensing~~, bioinformatics ~~workflows~~, instruments, and frontier research.~~</div>~~
	~~<div class="np-hero-note">Start with the concept, follow the evidence, and use reliable sources when adding new material.</div>~~
	~~</div>~~
	~~<div class="np-hero-image">[[File:Nanopore_sequencing_principle.png\|frameless\|330px\|link=https://www.nanopore.net/index.php?curid=2\|Principle of nanopore sequencing]]~~</div>
	</div>		</div>

			<div class="np-top-intro"><div class="np-intro-text">
	Nanopores are nanoscale openings that allow ions or molecules to pass through a membrane or solid-state material. When a molecule moves through or near a nanopore, it can change an electrical current, ion flow, or another measurable signal. These signal changes can be used to study DNA, RNA, proteins, small molecules, and other biological or chemical systems at single-molecule scale.		Nanopores are nanoscale openings that allow ions or molecules to pass through a membrane or solid-state material. When a molecule moves through or near a nanopore, it can change an electrical current, ion flow, or another measurable signal. These signal changes can be used to study DNA, RNA, proteins, small molecules, and other biological or chemical systems at single-molecule scale.
			</div><div class="np-intro-image">
			[[File:Nanopore_sequencing_principle.png\|frameless\|300px\|link=https://www.nanopore.net/index.php?curid=2\|Principle of nanopore sequencing]]
			<div class="np-caption">Principle of nanopore sequencing. Source: Wikimedia Commons, DBCLS, CC BY 4.0.</div>
			</div></div>

	<div class="np-grid"><div class="np-~~panel~~ np-blue"><h2>News and Research Updates</h2><div class="np-~~panel~~-~~body~~">		<div class="np-grid"><div class="np-box np-heading-blue"><h2>News and Research Updates</h2><div class="np-box-content">
	{{:Latest Progress}}		{{:Latest Progress}}
	</div></div>		</div></div>

	<div class="np-~~panel~~ np-green"><h2>Did You Know?</h2><div class="np-~~panel~~-~~body~~">		<div class="np-box np-heading-green"><h2>Did You Know?</h2><div class="np-box-content">
	* Nanopore sequencing reads molecular signals directly as DNA or RNA passes through a nanoscale pore.		* Nanopore sequencing reads molecular signals directly as DNA or RNA passes through a nanoscale pore.
	* Long reads can help resolve repeats, structural variants, and complex genome regions.		* Long reads can help resolve repeats, structural variants, and complex genome regions.
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	</div></div></div>		</div></div></div>

	<div class="np-grid"><div class="np-~~panel~~ np-~~purple~~"><h2>What Is a Nanopore?</h2><div class="np-~~panel~~-~~body~~">		<div class="np-grid"><div class="np-box np-heading-gray"><h2>What Is a Nanopore?</h2><div class="np-box-content">
	A nanopore is a very small opening, often only a few nanometres wide. In nanopore experiments, ions or molecules pass through or near the pore, and the resulting signal can be measured. The signal can carry information about molecular size, charge, shape, sequence, binding, or chemical modification.		A nanopore is a very small opening, often only a few nanometres wide. In nanopore experiments, ions or molecules pass through or near the pore, and the resulting signal can be measured. The signal can carry information about molecular size, charge, shape, sequence, binding, or chemical modification.

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	</div></div>		</div></div>

	<div class="np-~~panel~~ np-gold"><h2>Picture of the Day</h2><div class="np-~~panel-body np~~-~~picture~~">		<div class="np-box np-heading-gold"><h2>Picture of the Day</h2><div class="np-box-content">
	[[File:Nanopore_sequencing_principle.png\|frameless\|~~360px~~\|link=https://www.nanopore.net/index.php?curid=2\|Principle of nanopore sequencing]]		[[File:Nanopore_sequencing_principle.png\|frameless\|320px\|center\|link=https://www.nanopore.net/index.php?curid=2\|Principle of nanopore sequencing]]
	<div class="np-caption">A schematic view of nanopore sequencing, where molecular movement through a pore is converted into measurable signal.</div>		<div class="np-caption">A schematic view of nanopore sequencing, where molecular movement through a pore is converted into measurable signal.</div>
	</div></div></div>		</div></div></div>

	<div class="np-grid"><div class="np-~~panel~~ np-blue"><h2>Start Here</h2><div class="np-~~panel~~-~~body~~">		<div class="np-grid"><div class="np-box np-heading-blue"><h2>Start Here</h2><div class="np-box-content">
	* [[Nanopore technology]] - principles, pore types, signals, and measurement concepts.		* [[Nanopore technology]] - principles, pore types, signals, and measurement concepts.
	* [[Nanopore sequencing]] - how DNA and RNA sequencing with nanopores works.		* [[Nanopore sequencing]] - how DNA and RNA sequencing with nanopores works.
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	</div></div>		</div></div>

	<div class="np-~~panel~~ np-green"><h2>Applications</h2><div class="np-~~panel~~-~~body~~">		<div class="np-box np-heading-green"><h2>Applications</h2><div class="np-box-content">
	* Public health surveillance and pathogen genomics		* Public health surveillance and pathogen genomics
	* Clinical and infectious disease research		* Clinical and infectious disease research
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	</div></div></div>		</div></div></div>

	<div class="np-grid"><div class="np-~~panel~~ np-~~purple~~"><h2>Tools and Workflows</h2><div class="np-~~panel~~-~~body~~">		<div class="np-grid"><div class="np-box np-heading-gray"><h2>Tools and Workflows</h2><div class="np-box-content">
	* [[MinION]] and other portable sequencing instruments		* [[MinION]] and other portable sequencing instruments
	* [[Oxford Nanopore]] platforms and chemistry concepts		* [[Oxford Nanopore]] platforms and chemistry concepts
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	</div></div>		</div></div>

	<div class="np-~~panel~~ np-red"><h2>Nanopore Wiki Reminds You</h2><div class="np-~~panel~~-~~body~~">		<div class="np-box np-heading-red"><h2>Nanopore Wiki Reminds You</h2><div class="np-box-content">
	Nanopore Wiki is an educational and knowledge-organization project. Its pages are intended for science communication and general technical reference, and do not replace professional medical, legal, regulatory, or commercial advice. Claims about breakthroughs, clinical use, or product performance should be supported by reliable sources.		Nanopore Wiki is an educational and knowledge-organization project. Its pages are intended for science communication and general technical reference, and do not replace professional medical, legal, regulatory, or commercial advice. Claims about breakthroughs, clinical use, or product performance should be supported by reliable sources.
	</div></div></div>		</div></div></div>
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	<div class="np-project-grid">		<div class="np-project-grid">
	<div class="np-project~~-item~~"~~><div class="np-project-icon">G</div><div~~><div class="np-project-title">[[Glossary\|Glossary]]</div><div class="np-project-desc">Concise definitions for nanopore terms.~~</div>~~</div></div>		<div class="np-project"><div class="np-project-title">[[Glossary\|Glossary]]</div><div class="np-project-desc">Concise definitions for nanopore terms.</div></div>
	<div class="np-project~~-item~~"~~><div class="np-project-icon">N</div><div~~><div class="np-project-title">[[Latest Progress\|News and papers]]</div><div class="np-project-desc">Research updates, high-level papers, and technology progress.~~</div>~~</div></div>		<div class="np-project"><div class="np-project-title">[[Latest Progress\|News and papers]]</div><div class="np-project-desc">Research updates, high-level papers, and technology progress.</div></div>
	<div class="np-project~~-item"><div class="np-project-icon~~"~~>D</div><div~~><div class="np-project-title">[[Bioinformatics\|Data and bioinformatics]]</div><div class="np-project-desc">Workflows for signal, reads, mapping, assembly, and variants.~~</div>~~</div></div>		<div class="np-project"><div class="np-project-title">[[Bioinformatics\|Data and bioinformatics]]</div><div class="np-project-desc">Workflows for signal, reads, mapping, assembly, and variants.</div></div>
	<div class="np-project~~-item~~"~~><div class="np-project-icon">I</div><div~~><div class="np-project-title">[[MinION\|Instruments and workflows]]</div><div class="np-project-desc">Portable sequencing devices and practical methods.~~</div>~~</div></div>		<div class="np-project"><div class="np-project-title">[[MinION\|Instruments and workflows]]</div><div class="np-project-desc">Portable sequencing devices and practical methods.</div></div>
	<div class="np-project~~-item~~"~~><div class="np-project-icon">H</div><div~~><div class="np-project-title">[[Help:Contents\|Help]]</div><div class="np-project-desc">How to read, search, and contribute.~~</div>~~</div></div>		<div class="np-project"><div class="np-project-title">[[Help:Contents\|Help]]</div><div class="np-project-desc">How to read, search, and contribute.</div></div>
	<div class="np-project~~-item"><div class="np-project-icon~~"~~>E</div><div~~><div class="np-project-title">[[Nanopore Wiki:Editorial guidelines\|Editorial guidelines]]</div><div class="np-project-desc">Quality standards for rigorous writing and sourcing.~~</div>~~</div></div>		<div class="np-project"><div class="np-project-title">[[Nanopore Wiki:Editorial guidelines\|Editorial guidelines]]</div><div class="np-project-desc">Quality standards for rigorous writing and sourcing.</div></div>
	</div></div>		</div></div>

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2026-06-29T05:36:59Z

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FuzzyBot: Updating to match new version of source page

2026-06-29T05:01:21Z

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← Older revision		Revision as of 13:01, 29 June 2026
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	__NOTOC__		__NOTOC__
	<div style="border:1px solid #a2a9b1; background:#f8f9fa; padding:1.2em; margin-bottom:1em; overflow:hidden;">		<div style="border:1px solid #a2a9b1; background:#f8f9fa; padding:1.2em; margin-bottom:1em; overflow:hidden;">
	[[File:Nanopore_sequencing_principle.png\|thumb\|right\|360px\|Principle of nanopore sequencing. Source: Wikimedia Commons, DBCLS, CC BY 4.0.]]		[[File:Nanopore_sequencing_principle.png\|thumb\|right\|360px\|link=https://www.nanopore.net/index.php?curid=2\|Principle of nanopore sequencing. Source: Wikimedia Commons, DBCLS, CC BY 4.0.]]
	<div style="font-size:188%; line-height:1.2; margin-bottom:0.25em;">Welcome to Nanopore Wiki</div>		<div style="font-size:188%; line-height:1.2; margin-bottom:0.25em;">Welcome to Nanopore Wiki</div>
	<div style="font-size:108%; max-width:58em;">A knowledge base and science outreach site for nanopore technology, nanopore sequencing, single-molecule sensing, bioinformatics workflows, instruments, and frontier research.</div>		<div style="font-size:108%; max-width:58em;">A knowledge base and science outreach site for nanopore technology, nanopore sequencing, single-molecule sensing, bioinformatics workflows, instruments, and frontier research.</div>
	</div>		</div>

			Nanopores are nanoscale openings that allow ions or molecules to pass through a membrane or solid-state material. When a molecule moves through or near a nanopore, it can change an electrical current, ion flow, or another measurable signal. These signal changes can be used to study DNA, RNA, proteins, small molecules, and other biological or chemical systems at single-molecule scale.

			Nanopore methods matter because they can connect molecular events with real-time measurements. In sequencing, long DNA or RNA molecules pass through a pore and generate signals that can be converted into sequence information. In sensing, changes in current or other signals can reveal molecular size, charge, structure, binding, or chemical modification.

	{\| style="width:100%; border-spacing:10px; border-collapse:separate;"		{\| style="width:100%; border-spacing:10px; border-collapse:separate;"
	\| style="width:50%; vertical-align:top; border:1px solid #a2a9b1; background:#f8f9fa; padding:1em;" \|		\| style="width:50%; vertical-align:top; border:1px solid #a2a9b1; background:#f8f9fa; padding:1em;" \|
	== Start Here ==		== Start Here ==
	* [[Nanopore technology]]		* [[Nanopore technology]] - principles, pore types, signals, and measurement concepts.
	* [[Nanopore sequencing]]		* [[Nanopore sequencing]] - how DNA and RNA sequencing with nanopores works.
	* [[Single-molecule detection]]		* [[Single-molecule detection]] - how nanopores can detect individual molecules.
	* [[Bioinformatics]]		* [[Bioinformatics]] - basecalling, read mapping, assembly, variants, and quality control.
	* [[Glossary]]		* [[Glossary]] - concise definitions of common terms.

	~~Nanopores are nanoscale pores that~~ can ~~be used to observe molecules through changes~~ in ~~electrical current~~, ~~ion flow~~, ~~or other measurable signals~~. ~~This makes them useful for~~ sequencing, molecular ~~sensing, and real-time analysis~~.		\| style="width:50%; vertical-align:top; border:1px solid #a2a9b1; background:#f8f9fa; padding:1em;" \|
			== Why It Matters ==
			* Long reads can span repeats, structural variants, and complex genomic regions.
			* Real-time analysis can support rapid decisions in field, clinical, and laboratory settings.
			* Portable instruments make sequencing and sensing possible outside large sequencing centers.
			* Direct molecular measurements can preserve information about RNA, base modifications, or molecular context.

	~~\| style="width:50%; vertical-align:top; border:1px solid #a2a9b1; background:#f8f9fa; padding:1em;" \|~~
	~~== Latest Progress ==~~
	~~{{:Latest Progress}}~~
	\|-		\|-
	\| style="width:50%; vertical-align:top; border:1px solid #a2a9b1; background:#f8f9fa; padding:1em;" \|		\| style="width:50%; vertical-align:top; border:1px solid #a2a9b1; background:#f8f9fa; padding:1em;" \|
	== ~~Research Topics~~ ==		== Applications ==
	* ~~[[Long-read sequencing]]~~		* Public health surveillance and pathogen genomics
	* ~~[[Direct RNA sequencing]]~~		* Clinical and infectious disease research
	* ~~[[Epigenetic modification detection]]~~		* Environmental DNA and biodiversity monitoring
	* ~~[[Pathogen detection]]~~		* Microbiome and metagenomic analysis
	* ~~[[Environmental DNA]]~~		* Agriculture, food safety, and biosecurity
	* ~~[[Protein nanopore sensing]]~~		* Structural variation, genome assembly, RNA analysis, and epigenetic modification detection

	\| style="width:50%; vertical-align:top; border:1px solid #a2a9b1; background:#f8f9fa; padding:1em;" \|		\| style="width:50%; vertical-align:top; border:1px solid #a2a9b1; background:#f8f9fa; padding:1em;" \|
	== Tools and Workflows ==		== Tools and Workflows ==
	* [[MinION]]		* [[MinION]] and other portable sequencing instruments
	* [[Oxford Nanopore]]		* [[Oxford Nanopore]] platforms and chemistry concepts
	* [[Basecalling]]		* Basecalling from raw signal to sequence reads
	* [[Read mapping]]		* Read mapping, variant calling, genome assembly, and quality control
	* [[Variant calling]]		* Experimental design, metadata, reproducibility, and responsible interpretation
	* ~~[[Genome assembly]]~~
	* [[Quality control]]
	\|-		\|-
	\| style="width:50%; vertical-align:top; border:1px solid #a2a9b1; background:#f8f9fa; padding:1em;" \|		\| style="width:50%; vertical-align:top; border:1px solid #a2a9b1; background:#f8f9fa; padding:1em;" \|
	== ~~Applications~~ ==		== Latest Progress ==
	* Public health surveillance		{{:Latest Progress}}
	* Clinical and pathogen genomics
	* Agriculture and food safety
	* Environmental monitoring
	* Microbiome and metagenomics
	* Structural variant analysis

	\| style="width:50%; vertical-align:top; border:1px solid #a2a9b1; background:#f8f9fa; padding:1em;" \|		\| style="width:50%; vertical-align:top; border:1px solid #a2a9b1; background:#f8f9fa; padding:1em;" \|
	== Contribute ==		== Contribute ==
	~~Add new pages~~, ~~improve definitions~~, ~~summarize recent papers~~, and ~~keep methods pages up to date~~. ~~For new~~ progress items, ~~edit [[Latest Progress]] so the homepage updates automatically~~.		Nanopore Wiki welcomes careful contributions: clear definitions, reliable sources, reproducible methods, and balanced summaries of recent research. New progress items should include a date, a concise explanation, and a source when available.

			== Site Notes ==
			Nanopore Wiki is an educational and knowledge-organization project. Its pages are intended for science communication and general technical reference, and do not replace professional medical, legal, regulatory, or commercial advice.

	== References ==		== References ==

FuzzyBot: Updating to match new version of source page

2026-06-27T05:10:10Z

Updating to match new version of source page

New page

__NOTOC__
<div style="border:1px solid #a2a9b1; background:#f8f9fa; padding:1.2em; margin-bottom:1em; overflow:hidden;">
[[File:Nanopore_sequencing_principle.png|thumb|right|360px|Principle of nanopore sequencing. Source: Wikimedia Commons, DBCLS, CC BY 4.0.]]
<div style="font-size:188%; line-height:1.2; margin-bottom:0.25em;">Welcome to Nanopore Wiki</div>
<div style="font-size:108%; max-width:58em;">A knowledge base and science outreach site for nanopore technology, nanopore sequencing, single-molecule sensing, bioinformatics workflows, instruments, and frontier research.</div>
</div>

{| style="width:100%; border-spacing:10px; border-collapse:separate;"
| style="width:50%; vertical-align:top; border:1px solid #a2a9b1; background:#f8f9fa; padding:1em;" |
== Start Here ==
* [[Nanopore technology]]
* [[Nanopore sequencing]]
* [[Single-molecule detection]]
* [[Bioinformatics]]
* [[Glossary]]

Nanopores are nanoscale pores that can be used to observe molecules through changes in electrical current, ion flow, or other measurable signals. This makes them useful for sequencing, molecular sensing, and real-time analysis.

| style="width:50%; vertical-align:top; border:1px solid #a2a9b1; background:#f8f9fa; padding:1em;" |
== Latest Progress ==
{{:Latest Progress}}
|-
| style="width:50%; vertical-align:top; border:1px solid #a2a9b1; background:#f8f9fa; padding:1em;" |
== Research Topics ==
* [[Long-read sequencing]]
* [[Direct RNA sequencing]]
* [[Epigenetic modification detection]]
* [[Pathogen detection]]
* [[Environmental DNA]]
* [[Protein nanopore sensing]]

| style="width:50%; vertical-align:top; border:1px solid #a2a9b1; background:#f8f9fa; padding:1em;" |
== Tools and Workflows ==
* [[MinION]]
* [[Oxford Nanopore]]
* [[Basecalling]]
* [[Read mapping]]
* [[Variant calling]]
* [[Genome assembly]]
* [[Quality control]]
|-
| style="width:50%; vertical-align:top; border:1px solid #a2a9b1; background:#f8f9fa; padding:1em;" |
== Applications ==
* Public health surveillance
* Clinical and pathogen genomics
* Agriculture and food safety
* Environmental monitoring
* Microbiome and metagenomics
* Structural variant analysis

| style="width:50%; vertical-align:top; border:1px solid #a2a9b1; background:#f8f9fa; padding:1em;" |
== Contribute ==
Add new pages, improve definitions, summarize recent papers, and keep methods pages up to date. For new progress items, edit [[Latest Progress]] so the homepage updates automatically.

== References ==
* [https://en.wikipedia.org/wiki/Nanopore Nanopore - Wikipedia]
* [https://en.wikipedia.org/wiki/Nanopore_sequencing Nanopore sequencing - Wikipedia]
* [https://commons.wikimedia.org/wiki/File:202001_nanopore_sequencing.svg Principle of nanopore sequencing - Wikimedia Commons]
|}

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